Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation

[Image: see text] The first allosteric, type III inhibitor of LIM-kinase 2 (LIMK2) is reported. A series of molecules that feature both an N-phenylsulfonamide and tertiary amide were not only very potent at LIMK2 but also were extremely selective against a panel of other kinases. Enzymatic kinetic s...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Goodwin, Nicole C., Cianchetta, Giovanni, Burgoon, Hugh A., Healy, Jason, Mabon, Ross, Strobel, Eric D., Allen, Jason, Wang, Shuli, Hamman, Brian D., Rawlins, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291701/
https://ncbi.nlm.nih.gov/pubmed/25589930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500242y
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