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Kinase inhibitor profiling reveals unexpected opportunities to inhibit disease-associated mutant kinases
Small-molecule kinase inhibitors have typically been designed to inhibit wild-type kinases rather than the mutant forms that frequently arise in diseases such as cancer. Mutations can have serious clinical implications by increasing kinase catalytic activity or conferring therapeutic resistance. To...
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| Yayımlandı: | Cell Rep |
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| Asıl Yazarlar: | , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2016
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4740242/ https://ncbi.nlm.nih.gov/pubmed/26776524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.080 |
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