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Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design
PIK3CA , the gene that encodes the catalytic subunit of phosphatidylinositol 3-kinase α (PI3Kα), is frequently mutated in breast and other types of cancer. A specific inhibitor that targets the mutant forms of PI3Kα could maximize treatment efficiency while minimizing side-effects. Herein we describ...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5319926/ https://ncbi.nlm.nih.gov/pubmed/28129991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.01.012 |
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