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Allosteric Activation of PI3Kα Results in Dynamic Access to Catalytically Competent Conformations
Class I phosphoinositide-3-kinases (PI3Ks) phosphorylate PIP(2) at its 3′ inositol position to generate PIP(3), a second messenger that influences signaling cascades regulating cellular growth, survival, and proliferation. Previous studies have suggested that PI3Kα activation involves dislodging the...
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| Publicado no: | Structure |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8057532/ https://ncbi.nlm.nih.gov/pubmed/32049032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.01.010 |
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