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Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design
PIK3CA , the gene that encodes the catalytic subunit of phosphatidylinositol 3-kinase α (PI3Kα), is frequently mutated in breast and other types of cancer. A specific inhibitor that targets the mutant forms of PI3Kα could maximize treatment efficiency while minimizing side-effects. Herein we describ...
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| Gepubliceerd in: | Bioorg Med Chem |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5319926/ https://ncbi.nlm.nih.gov/pubmed/28129991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.01.012 |
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