Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit

We propose a novel model for the regulation of the p85/p110α phosphatidylinositol 3′-kinase. In insect cells, the p110α catalytic subunit is active as a monomer but its activity is decreased by coexpression with the p85 regulatory subunit. Similarly, the lipid kinase activity of recombinant glutathi...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Yu, Jinghua, Zhang, Yitao, McIlroy, James, Rordorf-Nikolic, Tamara, Orr, George A., Backer, Jonathan M.
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 1998
Fag:	Cell Growth and Development
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC108851/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9488453/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.3.1379
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