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c-Myc regulates transcriptional pause release

Recruitment of the RNA Polymerase II (Pol II) transcription initiation apparatus to promoters by specific DNA binding transcription factors is well recognized as a key regulatory step in gene expression. We report here that promoter-proximal pausing is a general feature of transcription by Pol II in...

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Detalhes bibliográficos
Main Authors: Rahl, Peter B., Lin, Charles Y., Seila, Amy C., Flynn, Ryan A., McCuine, Scott, Burge, Christopher B., Sharp, Phillip A., Young, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864022/
https://ncbi.nlm.nih.gov/pubmed/20434984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.03.030
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