EGFR mutations and resistance to Irreversible pyrimidine based EGFR inhibitors

Por Ercan, Dalia, Choi, Hwan Geun, Yun, Cai-Hong, Capelletti, Marzia, Xie, Ting, Eck, Michael J., Gray, Nathanael S., Jänne, Pasi A.
Publicado no Clin Cancer Res (2015)

Clinical and molecular characteristics of NF1 mutant lung cancer

Por Redig, Amanda J., Capelletti, Marzia, Dahlberg, Suzanne E., Sholl, Lynette M., Mach, Stacy, Fontes, Caitlin, Shi, Yunling, Chalasani, Poornima, Jänne, Pasi A.
Publicado no Clin Cancer Res (2016)

Combined EGFR/MEK Inhibition Prevents the Emergence of Resistance in EGFR mutant Lung Cancer

Por Tricker, Erin M., Xu, Chunxiao, Uddin, Sharmeen, Capelletti, Marzia, Ercan, Dalia, Ogino, Atsuko, Pratilas, Christine A., Rosen, Neal, Gray, Nathanael S., Wong, Kwok-Kin, Jänne, Pasi A.
Publicado no Cancer Discov (2015)

Identification of existing drugs that effectively target NTRK1- and ROS1-rearrangements in lung cancer

Por Chong, Curtis R., Bahcall, Magda, Capelletti, Marzia, Kosaka, Takayuki, Ercan, Dalia, Sim, Taebo, Sholl, Lynette M., Nishino, Mizuki, Johnson, Bruce E., Gray, Nathanael S., Jänne, Pasi A.
Publicado no Clin Cancer Res (2016)

Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor

Por Ercan, Dalia, Zejnullahu, Kreshnik, Yonesaka, Kimio, Xiao, Yun, Capelletti, Marzia, Rogers, Andrew, Lifshits, Eugene, Brown, Alison, Lee, Charles, Christensen, James G., Kwiatkowski, David J., Engelman, Jeffrey A., Jänne, Pasi A.
Publicado em 2010

A Pooled Exploratory Analysis of the Effect of Tumor Size and KRAS Mutations on Survival Benefit from Adjuvant Platinum-Based Chemotherapy in Node Negative Non-Small Cell Lung Canc...

Por Cuffe, Sinead, Bourredjem, Abderrahmane, Graziano, Stephen, Pignon, Jean-Pierre, Domerg, Caroline, Ezzalfani, Monia, Seymour, Lesley, Strevel, Elizabeth, Burkes, Ronald, Capelletti, Marzia, Jänne, Pasi A., Tsao, Ming-Sound, Shepherd, Frances A.
Publicado em 2012

Randomized Phase II Trial of Erlotinib Alone or With Carboplatin and Paclitaxel in Patients Who Were Never or Light Former Smokers With Advanced Lung Adenocarcinoma: CALGB 30406 Tr...

Por Jänne, Pasi A., Wang, Xiaofei, Socinski, Mark A., Crawford, Jeffrey, Stinchcombe, Thomas E., Gu, Lin, Capelletti, Marzia, Edelman, Martin J., Villalona-Calero, Miguel A., Kratzke, Robert, Vokes, Everett E., Miller, Vincent A.
Publicado em 2012

The neuroblastoma associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK translocated cancers

Por Sasaki, Takaaki, Okuda, Katsuhiro, Zheng, Wei, Butrynski, James, Capelletti, Marzia, Wang, Liping, Gray, Nathanael S., Wilner, Keith, Christensen, James G., Demetri, George, Shapiro, Geoffrey I., Rodig, Scott J., Eck, Michael J., Jänne, Pasi A.
Publicado em 2010

EGFR Exon 19 Insertions: A New Family of Sensitizing EGFR Mutations in Lung Adenocarcinoma

Por He, Mai, Capelletti, Marzia, Nafa, Khedoudja, Yun, Cai-Hong, Arcila, Maria E., Miller, Vincent A., Ginsberg, Michelle S., Zhao, Binsheng, Kris, Mark G., Eck, Michael J., Jänne, Pasi A., Ladanyi, Marc, Oxnard, Geoffrey R.
Publicado em 2011

Novel mutant-selective EGFR kinase inhibitors against EGFR T790M

Por Zhou, Wenjun, Ercan, Dalia, Chen, Liang, Yun, Cai-hong, Li, Danan, Capelletti, Marzia, Cortot, Alexis B., Chirieac, Lucian, Iacob, Roxana E., Padera, Robert, Engen, John R., Wong, Kwok-Kin, Eck, Michael J., Gray, Nathanael S., Jänne, Pasi A.
Publicado em 2009

Intratumoral heterogeneity in EGFR mutant NSCLC results in divergent resistance mechanisms in response to EGFR tyrosine kinase inhibition

Por Soucheray, Margaret, Capelletti, Marzia, Pulido, Inés, Kuang, Yanan, Paweletz, Cloud P., Becker, Jeffrey H., Kikuchi, Eiki, Xu, Chunxiao, Patel, Tarun B., Al-shahrour, Fatima, Carretero, Julián, Wong, Kwok-Kin, Jänne, Pasi A., Shapiro, Geoffrey I., Shimamura, Takeshi
Publicado no Cancer Res (2015)

Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance

Por Johnson, Neil, Johnson, Shawn F., Yao, Wei, Li, Yu-Chen, Choi, Young-Eun, Bernhardy, Andrea J., Wang, Yifan, Capelletti, Marzia, Sarosiek, Kristopher A., Moreau, Lisa A., Chowdhury, Dipanjan, Wickramanayake, Anneka, Harrell, Maria I., Liu, Joyce F., D’Andrea, Alan D., Miron, Alexander, Swisher, Elizabeth M., Shapiro, Geoffrey I.
Publicado em 2013

Pre-existence and clonal selection of MET amplification in EGFR mutant NSCLC

Por Turke, Alexa B., Zejnullahu, Kreshnik, Wu, Yi-Long, Song, Youngchul, Dias-Santagata, Dora, Lifshits, Eugene, Toschi, Luca, Rogers, Andrew, Mok, Tony, Sequist, Lecia, Lindeman, Neal I., Murphy, Carly, Akhavanfard, Sara, Yeap, Beow Y., Xiao, Yun, Capelletti, Marzia, Iafrate, A. John, Lee, Charles, Christensen, James G., Engelman, Jeffrey A., Jänne, Pasi A.
Publicado em 2010

A Functional Landscape of Resistance to ALK Inhibition in Lung Cancer

Por Wilson, Frederick H., Johannessen, Cory M., Piccioni, Federica, Tamayo, Pablo, Kim, Jong Wook, Van Allen, Eliezer M., Corsello, Steven M., Capelletti, Marzia, Calles, Antonio, Butaney, Mohit, Sharifnia, Tanaz, Gabriel, Stacey B., Mesirov, Jill P., Hahn, William C., Engelman, Jeffrey A., Meyerson, Matthew, Root, David E., Jänne, Pasi A., Garraway, Levi A.
Publicado no Cancer Cell (2015)

Efficacy of a cancer vaccine against ALK-rearranged lung tumors

Por Voena, Claudia, Menotti, Matteo, Mastini, Cristina, Di Giacomo, Filomena, Longo, Dario Livio, Castella, Barbara, Merlo, Maria Elena Boggio, Ambrogio, Chiara, Wang, Qi, Minero, Valerio Giacomo, Poggio, Teresa, Martinengo, Cinzia, D'Amico, Lucia, Panizza, Elena, Mologni, Luca, Cavallo, Federica, Altruda, Fiorella, Butaney, Mohit, Capelletti, Marzia, Inghirami, Giorgio, Jänne, Pasi A., Chiarle, Roberto
Publicado no Cancer Immunol Res (2015)

Pooled Analysis of the Prognostic and Predictive Effects of KRAS Mutation Status and KRAS Mutation Subtype in Early-Stage Resected Non–Small-Cell Lung Cancer in Four Trials of Adju...

Por Shepherd, Frances A., Domerg, Caroline, Hainaut, Pierre, Jänne, Pasi A., Pignon, Jean-Pierre, Graziano, Stephen, Douillard, Jean-Yves, Brambilla, Elizabeth, Le Chevalier, Thierry, Seymour, Lesley, Bourredjem, Abderrahmane, Teuff, Gwénaël Le, Pirker, Robert, Filipits, Martin, Rosell, Rafael, Kratzke, Robert, Bandarchi, Bizhan, Ma, Xiaoli, Capelletti, Marzia, Soria, Jean-Charles, Tsao, Ming-Sound
Publicado no J Clin Oncol (2013)

Crizotinib in ALK-Rearranged Inflammatory Myofibroblastic Tumor

Por Butrynski, James E., D’Adamo, David R., Hornick, Jason L., Cin, Paola Dal, Antonescu, Cristina R., Jhanwar, Suresh C., Ladanyi, Marc, Capelletti, Marzia, Rodig, Scott J., Ramaiya, Nikhil, Kwak, Eunice L., Clark, Jeffrey W., Wilner, Keith D., Christensen, James G., Jänne, Pasi A., Maki, Robert G., Demetri, George D., Shapiro, Geoffrey I.
Publicado em 2010

Reactivation of ERK Signaling causes resistance to EGFR kinase inhibitors

Por Ercan, Dalia, Xu, Chunxiao, Yanagita, Masahiko, Monast, Calixte S., Pratilas, Christine A., Montero, Joan, Butaney, Mohit, Shimamura, Takeshi, Sholl, Lynette, Ivanova, Elena V., Tadi, Madhavi, Rogers, Andrew, Repellin, Claire, Capelletti, Marzia, Maertens, Ophélia, Goetz, Eva M., Letai, Anthony, Garraway, Levi A., Lazzara, Matthew J., Rosen, Neal, Gray, Nathanael S., Wong, Kwok-Kin, Jänne, Pasi A.
Publicado em 2012

Inhibition of ALK, PI3K/MEK, and HSP90 in Murine Lung Adenocarcinoma Induced by EML4-ALK Fusion Oncogene

Por Chen, Zhao, Sasaki, Takaaki, Tan, Xiaohong, Carretero, Julian, Shimamura, Takeshi, Li, Danan, Xu, Chunxiao, Wang, Yuchuan, Adelmant, Guillaume O., Capelletti, Marzia, Lee, Hyun Joo, Rodig, Scott J., Borgman, Christa, Park, Seung-il, Kim, Hyeong Ryul, Padera, Robert, Marto, Jarrod A., Gray, Nathanael S., Kung, Andrew L., Shapiro, Geoffrey I., Jänne, Pasi A., Wong, Kwok-Kin
Publicado em 2010

Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors

Por Tan, Li, Wang, Jun, Tanizaki, Junko, Huang, Zhifeng, Aref, Amir R., Rusan, Maria, Zhu, Su-Jie, Zhang, Yiyun, Ercan, Dalia, Liao, Rachel G., Capelletti, Marzia, Zhou, Wenjun, Hur, Wooyoung, Kim, NamDoo, Sim, Taebo, Gaudet, Suzanne, Barbie, David A., Yeh, Jing-Ruey Joanna, Yun, Cai-Hong, Hammerman, Peter S., Mohammadi, Moosa, Jänne, Pasi A., Gray, Nathanael S.
Publicado no Proc Natl Acad Sci U S A (2014)