Inhibition of ALK, PI3K/MEK, and HSP90 in Murine Lung Adenocarcinoma Induced by EML4-ALK Fusion Oncogene

Genetic rearrangements of the anaplastic lymphoma kinase (ALK) kinase occur in 3% to 13% of non–small cell lung cancer patients and rarely coexist with KRAS or EGFR mutations. To evaluate potential treatment strategies for lung cancers driven by an activated EML4-ALK chimeric oncogene, we generated...

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Main Authors: Chen, Zhao, Sasaki, Takaaki, Tan, Xiaohong, Carretero, Julian, Shimamura, Takeshi, Li, Danan, Xu, Chunxiao, Wang, Yuchuan, Adelmant, Guillaume O., Capelletti, Marzia, Lee, Hyun Joo, Rodig, Scott J., Borgman, Christa, Park, Seung-il, Kim, Hyeong Ryul, Padera, Robert, Marto, Jarrod A., Gray, Nathanael S., Kung, Andrew L., Shapiro, Geoffrey I., Jänne, Pasi A., Wong, Kwok-Kin
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3043107/
https://ncbi.nlm.nih.gov/pubmed/20952506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1671
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