EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer

PURPOSE: The EML4-ALK fusion gene has been detected in ~7% of Japanese non-small cell lung cancers (NSCLC). We determined the frequency of EML4-ALK in Caucasian NSCLCs and in NSCLC cell lines. We also determined whether TAE684, a specific ALK kinase inhibitor, would inhibit the growth of EML4-ALK co...

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Main Authors: Koivunen, Jussi P., Mermel, Craig, Zejnullahu, Kreshnik, Murphy, Carly, Lifshits, Eugene, Holmes, Alison J., Choi, Hwan Geun, Kim, Jhingook, Chiang, Derek, Thomas, Roman, Lee, Jinseon, Richards, William G., Sugarbaker, David J., Ducko, Christopher, Lindeman, Neal, Marcoux, J. Paul, Engelman, Jeffrey A., Gray, Nathanael S., Lee, Charles, Meyerson, Matthew, Jänne, Pasi A.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025451/
https://ncbi.nlm.nih.gov/pubmed/18594010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-0168
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