EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer

PURPOSE: The EML4-ALK fusion gene has been detected in ~7% of Japanese non-small cell lung cancers (NSCLC). We determined the frequency of EML4-ALK in Caucasian NSCLCs and in NSCLC cell lines. We also determined whether TAE684, a specific ALK kinase inhibitor, would inhibit the growth of EML4-ALK co...

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Detaylı Bibliyografya
Asıl Yazarlar: Koivunen, Jussi P., Mermel, Craig, Zejnullahu, Kreshnik, Murphy, Carly, Lifshits, Eugene, Holmes, Alison J., Choi, Hwan Geun, Kim, Jhingook, Chiang, Derek, Thomas, Roman, Lee, Jinseon, Richards, William G., Sugarbaker, David J., Ducko, Christopher, Lindeman, Neal, Marcoux, J. Paul, Engelman, Jeffrey A., Gray, Nathanael S., Lee, Charles, Meyerson, Matthew, Jänne, Pasi A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2008
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025451/
https://ncbi.nlm.nih.gov/pubmed/18594010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-0168
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