Characterization of TAE684 as a potent LRRK2 kinase inhibitor

por Zhang, Jinwei, Deng, Xianming, Choi, Hwan Geun, Alessi, Dario R., Gray, Nathanael S.
Publicado 2012

Development of ‘DFG-out’ inhibitors of gatekeeper mutant kinases

por Choi, Hwan Geun, Zhang, Jianming, Weisberg, Ellen, Griffin, James D., Sim, Taebo, Gray, Nathanael S.
Publicado 2012

Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor

por Hatcher, John M., Zhang, Jinwei, Choi, Hwan Geun, Ito, Genta, Alessi, Dario R., Gray, Nathanael S.
Publicado en ACS Med Chem Lett (2015)

Structural basis of mutant-selectivity and drug-resistance related to CO-1686

por Yan, Xiao-E, Zhu, Su-Jie, Liang, Ling, Zhao, Peng, Choi, Hwan Geun, Yun, Cai-Hong
Publicado en Oncotarget (2017)

Essential Role for IKKβ in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells

por Pauls, Eduardo, Shpiro, Natalia, Peggie, Mark, Young, Erick R., Sorcek, Ronald J., Tan, Li, Choi, Hwan Geun, Cohen, Philip
Publicado 2012

Discovery of inhibitors that overcome the G1202R ALK Resistance Mutation

por Hatcher, John M., Bahcall, Magda, Choi, Hwan Geun, Gao, Yang, Sim, Taebo, George, Rani, Jänne, Pasi A., Gray, Nathanael S.
Publicado en J Med Chem (2015)

Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor–associated kinase 4 (IRAK4)

por Wang, Li, Ferrao, Ryan, Li, Qiubai, Hatcher, John M., Choi, Hwan Geun, Buhrlage, Sara J., Gray, Nathanael S., Wu, Hao
Publicado en J Biol Chem (2019)

Brain Penetrant LRRK2 Inhibitor

por Choi, Hwan Geun, Zhang, Jinwei, Deng, Xianming, Hatcher, John M., Patricelli, Matthew P., Zhao, Zheng, Alessi, Dario R., Gray, Nathanael S.
Publicado 2012

EGFR mutations and resistance to Irreversible pyrimidine based EGFR inhibitors

por Ercan, Dalia, Choi, Hwan Geun, Yun, Cai-Hong, Capelletti, Marzia, Xie, Ting, Eck, Michael J., Gray, Nathanael S., Jänne, Pasi A.
Publicado en Clin Cancer Res (2015)

KF-1607, a Novel Pan Src Kinase Inhibitor, Attenuates Obstruction-Induced Tubulointerstitial Fibrosis in Mice

por Dorotea, Debra, Lee, Seungyeon, Lee, Sun Joo, Lee, Gayoung, Son, Jung Beom, Choi, Hwan Geun, Ahn, Sung-Min, Ha, Hunjoo
Publicado en Biomol Ther (Seoul) (2021)

A Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region

por Moroco, Jamie A., Baumgartner, Matthew P., Rust, Heather L., Choi, Hwan Geun, Hur, Wooyoung, Gray, Nathanael S., Camacho, Carlos J., Smithgall, Thomas E.
Publicado en Chem Biol Drug Des (2014)

Beneficial effects of combining a Type II ATP competitive inhibitor with an allosteric competitive inhibitor of Bcr-Abl for the treatment of imatinib-sensitive and imatinib resista...

por Weisberg, Ellen, Deng, Xianming, Choi, Hwan Geun, Barrett, Rosemary, Adamia, Sophia, Ray, Arghya, Moreno, Daisy, Kung, Andrew L., Gray, Nathanael, Griffin, James D.
Publicado 2010

Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stability

por Liu, Qingsong, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Hur, Wooyoung, Choi, Hwan Geun, Waller, David L., Sim, Taebo, Sabatini, David M., Gray, Nathanael S.
Publicado 2011

GSK2578215A; A potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor

por Reith, Alastair D., Bamborough, Paul, Jandu, Karamjit, Andreotti, Daniele, Mensah, Lucy, Dossang, Pamela, Choi, Hwan Geun, Deng, Xianming, Zhang, Jinwei, Alessi, Dario R., Gray, Nathanael S.
Publicado 2012

EphA2 is a Mediator of Vemurafenib Resistance and a Novel Therapeutic Target in Melanoma

por Miao, Benchun, Ji, Zhenyu, Tan, Li, Taylor, Michael, Zhang, Jianming, Choi, Hwan Geun, Frederick, Dennie T., Kumar, Raj, Wargo, Jennifer A., Flaherty, Keith T., Gray, Nathanael S., Tsao, Hensin
Publicado en Cancer Discov (2014)

Discovery of a Potent Dual ALK and EGFR T790M Inhibitor

por Jang, Jaebong, Son, Jung Beom, To, Ciric, Bahcall, Magda, Kim, So Young, Kang, Seock Yong, Mushajiang, Mierzhati, Lee, Younho, Jänne, Pasi A., Choi, Hwan Geun, Gray, Nathanael S.
Publicado en Eur J Med Chem (2017)

Covalent Guanosine Mimetic Inhibitors of G12C KRAS

por Xiong, Yuan, Lu, Jia, Hunter, John, Li, Lianbo, Scott, David, Choi, Hwan Geun, Lim, Sang Min, Manandhar, Anuj, Gondi, Sudershan, Sim, Taebo, Westover, Kenneth D., Gray, Nathanael S.
Publicado en ACS Med Chem Lett (2016)

Brain injury induces HIF-1α-dependent transcriptional activation of LRRK2 that exacerbates brain damage

por Bae, Yun-Hee, Joo, Hyejin, Bae, Jinhyun, Hyeon, Seung Jae, Her, Song, Ko, Eunhwa, Choi, Hwan Geun, Ryu, Hoon, Hur, Eun-Mi, Bu, Youngmin, Lee, Byoung Dae
Publicado en Cell Death Dis (2018)

Small Molecule Inhibitors of the c-Fes Protein-tyrosine Kinase

por Hellwig, Sabine, Miduturu, Chandra V., Kanda, Shigeru, Zhang, Jianming, Filippakopoulos, Panagis, Salah, Eidarus, Deng, Xianming, Choi, Hwan Geun, Zhou, Wenjun, Hur, Wooyoung, Knapp, Stefan, Gray, Nathanael S., Smithgall, Thomas E.
Publicado 2012

In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C

por Hunter, John C., Gurbani, Deepak, Ficarro, Scott B., Carrasco, Martin A., Lim, Sang Min, Choi, Hwan Geun, Xie, Ting, Marto, Jarrod A., Chen, Zhe, Gray, Nathanael S., Westover, Kenneth D.
Publicado 2014