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Characterization of TAE684 as a potent LRRK2 kinase inhibitor
Leucine-rich repeat kinase 2 (LRRK2) is linked to Parkinson’s disease and may represent an attractive therapeutic target. Here we report a 2,4-dianilino-5-chloro-pyrimidine, TAE684, a previously reported inhibitor of anaplastic lymphoma kinase (ALK), is also a potent inhibitor of LRRK2 kinase activi...
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| Hoofdauteurs: | , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2012
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3433743/ https://ncbi.nlm.nih.gov/pubmed/22335897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.01.084 |
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