Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK

Constitutive overexpression and activation of NPM-ALK fusion protein [t(2:5)(p23;q35)] is a key oncogenic event that drives the survival and proliferation of anaplastic large-cell lymphomas (ALCLs). We have identified a highly potent and selective small-molecule ALK inhibitor, NVP-TAE684, which bloc...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Galkin, Anna V., Melnick, Jonathan S., Kim, Sungjoon, Hood, Tami L., Li, Nanxin, Li, Lintong, Xia, Gang, Steensma, Ruo, Chopiuk, Greg, Jiang, Jiqing, Wan, Yongqin, Ding, Peter, Liu, Yi, Sun, Fangxian, Schultz, Peter G., Gray, Nathanael S., Warmuth, Markus
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1765448/
https://ncbi.nlm.nih.gov/pubmed/17185414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609412103
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items