Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK

Constitutive overexpression and activation of NPM-ALK fusion protein [t(2:5)(p23;q35)] is a key oncogenic event that drives the survival and proliferation of anaplastic large-cell lymphomas (ALCLs). We have identified a highly potent and selective small-molecule ALK inhibitor, NVP-TAE684, which bloc...

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Hlavní autoři: Galkin, Anna V., Melnick, Jonathan S., Kim, Sungjoon, Hood, Tami L., Li, Nanxin, Li, Lintong, Xia, Gang, Steensma, Ruo, Chopiuk, Greg, Jiang, Jiqing, Wan, Yongqin, Ding, Peter, Liu, Yi, Sun, Fangxian, Schultz, Peter G., Gray, Nathanael S., Warmuth, Markus
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1765448/
https://ncbi.nlm.nih.gov/pubmed/17185414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609412103
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