Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK

Constitutive overexpression and activation of NPM-ALK fusion protein [t(2:5)(p23;q35)] is a key oncogenic event that drives the survival and proliferation of anaplastic large-cell lymphomas (ALCLs). We have identified a highly potent and selective small-molecule ALK inhibitor, NVP-TAE684, which bloc...

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Detalhes bibliográficos
Main Authors: Galkin, Anna V., Melnick, Jonathan S., Kim, Sungjoon, Hood, Tami L., Li, Nanxin, Li, Lintong, Xia, Gang, Steensma, Ruo, Chopiuk, Greg, Jiang, Jiqing, Wan, Yongqin, Ding, Peter, Liu, Yi, Sun, Fangxian, Schultz, Peter G., Gray, Nathanael S., Warmuth, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1765448/
https://ncbi.nlm.nih.gov/pubmed/17185414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609412103
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