Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK

Constitutive overexpression and activation of NPM-ALK fusion protein [t(2:5)(p23;q35)] is a key oncogenic event that drives the survival and proliferation of anaplastic large-cell lymphomas (ALCLs). We have identified a highly potent and selective small-molecule ALK inhibitor, NVP-TAE684, which bloc...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Galkin, Anna V., Melnick, Jonathan S., Kim, Sungjoon, Hood, Tami L., Li, Nanxin, Li, Lintong, Xia, Gang, Steensma, Ruo, Chopiuk, Greg, Jiang, Jiqing, Wan, Yongqin, Ding, Peter, Liu, Yi, Sun, Fangxian, Schultz, Peter G., Gray, Nathanael S., Warmuth, Markus
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2007
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1765448/
https://ncbi.nlm.nih.gov/pubmed/17185414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609412103
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