In vivo selection for metastasis promoting genes in the mouse

por Gumireddy, Kiranmai, Sun, Fangxian, Klein-Szanto, Andres J., Gibbins, Jonathan M., Gimotty, Phyllis A., Saunders, Aleister J., Schultz, Peter G., Huang, Qihong
Publicado 2007

A Type-II Kinase Inhibitor Capable of Inhibiting the T315I “Gatekeeper” mutant of Bcr-Abl

por Choi, Hwan Geun, Ren, Pingda, Adrian, Francisco, Sun, Fangxian, Lee, Hyun Soo, Wang, Xia, Ding, Qiang, Zhang, Guobao, Zhang, Yongping, Liu, Yi, Tuntland, Tove, Warmuth, Markus, Manley, Paul W., Mestan, Jürgen, Gray, Nathanael S, Sim, Taebo
Publicado 2010

Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors

por Cheng, Dai, Liu, Jun, Han, Dong, Zhang, Guobao, Gao, Wenqi, Hsieh, Mindy H., Ng, Nicholas, Kasibhatla, Shailaja, Tompkins, Celin, Li, Jie, Steffy, Auzon, Sun, Fangxian, Li, Chun, Seidel, H. Martin, Harris, Jennifer L., Pan, Shifeng
Publicado en ACS Med Chem Lett (2016)

Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK

por Galkin, Anna V., Melnick, Jonathan S., Kim, Sungjoon, Hood, Tami L., Li, Nanxin, Li, Lintong, Xia, Gang, Steensma, Ruo, Chopiuk, Greg, Jiang, Jiqing, Wan, Yongqin, Ding, Peter, Liu, Yi, Sun, Fangxian, Schultz, Peter G., Gray, Nathanael S., Warmuth, Markus
Publicado 2007

Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models

por Albaugh, Pam, Fan, Yi, Mi, Yuan, Sun, Fangxian, Adrian, Francisco, Li, Nanxin, Jia, Yong, Sarkisova, Yelena, Kreusch, Andreas, Hood, Tami, Lu, Min, Liu, Guoxun, Huang, Shenlin, Liu, Zuosheng, Loren, Jon, Tuntland, Tove, Karanewsky, Donald S., Seidel, H. Martin, Molteni, Valentina
Publicado 2012

Combination of PIM and JAK2 inhibitors synergistically suppresses cell proliferation and overcomes drug resistance of myeloproliferative neoplasms

por Huang, Shih-Min A., Wang, Anlai, Greco, Rita, Li, Zhifang, Sun, Fangxian, Barberis, Claude, Tabart, Michel, Patel, Vinod, Schio, Laurent, Hurley, Raelene, Chen, Bo, Cheng, Hong, Lengauer, Christoph, Pollard, Jack, Watters, James, Garcia-Echeverria, Carlos, Wiederschain, Dmitri, Adrian, Francisco, Zhang, JingXin
Publicado 2014

An experimental model of anti-PD-1 resistance exhibits activation of TGFß and Notch pathways and is sensitive to local mRNA immunotherapy

por Bernardo, Marie, Tolstykh, Tatiana, Zhang, Yu-an, Bangari, Dinesh S., Cao, Hui, Heyl, Kerstin A., Lee, Joon Sang, Malkova, Natalia V., Malley, Katie, Marquez, Eladio, Pollard, Jack, Qu, Hui, Roberts, Errin, Ryan, Sue, Singh, Kuldeep, Sun, Fangxian, Wang, Emma, Bahjat, Keith, Wiederschain, Dmitri, Wagenaar, Timothy R.
Publicado en Oncoimmunology (2021)

Oncogenic dependency on β-catenin in liver cancer cell lines correlates with pathway activation

por Ding, Zhihu, Shi, Chaomei, Jiang, Lan, Tolstykh, Tatiana, Cao, Hui, Bangari, Dinesh S., Ryan, Susan, Levit, Mikhail, Jin, Taiguang, Mamaat, Karl, Yu, Qunyan, Qu, Hui, Hopke, Joern, Cindhuchao, May, Hoffmann, Dietmar, Sun, Fangxian, Helms, Mike W., Jahn-Hofmann, Kerstin, Scheidler, Sabine, Schweizer, Liang, Fang, Douglas D., Pollard, Jack, Winter, Christopher, Wiederschain, Dmitri
Publicado en Oncotarget (2017)

Identification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cells

por Wagenaar, Timothy R., Tolstykh, Tatiana, Shi, Chaomei, Jiang, Lan, Zhang, JingXin, Li, Zhifang, Yu, Qunyan, Qu, Hui, Sun, Fangxian, Cao, Hui, Pollard, Jack, Dai, Shujia, Gao, Qiang, Zhang, Bailin, Arlt, Heike, Cindhuchao, May, Hoffmann, Dietmar, Light, Madelyn, Jensen, Karin, Hopke, Joern, Newcombe, Richard, Garcia-Echeverria, Carlos, Winter, Christopher, Zabludoff, Sonya, Wiederschain, Dmitri
Publicado en Nucleic Acids Res (2015)

Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma

por Liu, Haibo, Niu, Deqiang, Tham Sjin, Robert Tjin, Dubrovskiy, Alex, Zhu, Zhendong, McDonald, Joseph J., Fahnoe, Kelly, Wang, Zhigang, Munson, Mark, Scholte, Andrew, Barrague, Matthieu, Fitzgerald, Maria, Liu, Jinyu, Kothe, Michael, Sun, Fangxian, Murtie, Joshua, Ge, Jie, Rocnik, Jennifer, Harvey, Darren, Ospina, Beatriz, Perron, Keli, Zheng, Gang, Shehu, Elvis, D’Agostino, Laura Akullian
Publicado en ACS Med Chem Lett (2020)

Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist

por Pan, Shifeng, Wu, Xu, Jiang, Jiqing, Gao, Wenqi, Wan, Yongqin, Cheng, Dai, Han, Dong, Liu, Jun, Englund, Nathan P., Wang, Yan, Peukert, Stefan, Miller-Moslin, Karen, Yuan, Jing, Guo, Ribo, Matsumoto, Melissa, Vattay, Anthony, Jiang, Yun, Tsao, Jeffrey, Sun, Fangxian, Pferdekamper, AnneMarie C., Dodd, Stephanie, Tuntland, Tove, Maniara, Wieslawa, Kelleher, Joseph F., Yao, Yung-mae, Warmuth, Markus, Williams, Juliet, Dorsch, Marion
Publicado 2010

Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents

por Griebel, Guy, Pichat, Philippe, Beeské, Sandra, Leroy, Thibaud, Redon, Nicolas, Jacquet, Agnès, Françon, Dominique, Bert, Lionel, Even, Luc, Lopez-Grancha, Mati, Tolstykh, Tatiana, Sun, Fangxian, Yu, Qunyan, Brittain, Scott, Arlt, Heike, He, Timothy, Zhang, Bailin, Wiederschain, Dmitri, Bertrand, Thomas, Houtmann, Jacques, Rak, Alexey, Vallée, François, Michot, Nadine, Augé, Franck, Menet, Véronique, Bergis, Olivier E., George, Pascal, Avenet, Patrick, Mikol, Vincent, Didier, Michel, Escoubet, Johanna
Publicado en Sci Rep (2015)

Targeting wild-type and T315I Bcr-Abl by combining allosteric with ATP-site inhibitors

por Zhang, Jianming, Adrián, Francisco J., Jahnke, Wolfgang, Cowan-Jacob, Sandra W., Li, Allen G., Iacob, Roxana E., Sim, Taebo, Powers, John, Dierks, Christine, Sun, Fangxian, Guo, Gui-Rong, Ding, Qiang, Okram, Barun, Choi, Yongmun, Wojciechowski, Amy, Deng, Xianming, Liu, Guoxun, Fendrich, Gabriele, Strauss, Andre, Vajpai, Navratna, Grzesiek, Stephan, Tuntland, Tove, Liu, Yi, Bursulaya, Badry, Azam, Mohammad, Manley, Paul W., Engen, John R., Daley, George Q., Warmuth, Markus, Gray, Nathanael S.
Publicado 2010

(R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors

por Choi, Ha-Soon, Rucker, Paul V., Wang, Zhicheng, Fan, Yi, Albaugh, Pamela, Chopiuk, Greg, Gessier, Francois, Sun, Fangxian, Adrian, Francisco, Liu, Guoxun, Hood, Tami, Li, Nanxin, Jia, Yong, Che, Jianwei, McCormack, Susan, Li, Allen, Li, Jie, Steffy, Auzon, Culazzo, AnneMarie, Tompkins, Celine, Phung, Van, Kreusch, Andreas, Lu, Min, Hu, Bin, Chaudhary, Apurva, Prashad, Mahavir, Tuntland, Tove, Liu, Bo, Harris, Jennifer, Seidel, H. Martin, Loren, Jon, Molteni, Valentina
Publicado en ACS Med Chem Lett (2015)

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

por Liu, Jun, Pan, Shifeng, Hsieh, Mindy H., Ng, Nicholas, Sun, Fangxian, Wang, Tao, Kasibhatla, Shailaja, Schuller, Alwin G., Li, Allen G., Cheng, Dai, Li, Jie, Tompkins, Celin, Pferdekamper, AnneMarie, Steffy, Auzon, Cheng, Jane, Kowal, Colleen, Phung, Van, Guo, Guirong, Wang, Yan, Graham, Martin P., Flynn, Shannon, Brenner, J. Chad, Li, Chun, Villarroel, M. Cristina, Schultz, Peter G., Wu, Xu, McNamara, Peter, Sellers, William R., Petruzzelli, Lilli, Boral, Anthony L., Seidel, H. Martin, McLaughlin, Margaret E., Che, Jianwei, Carey, Thomas E., Vanasse, Gary, Harris, Jennifer L.
Publicado 2013