Hydrogen exchange mass spectrometry: Are we out of the quicksand?

Por Iacob, Roxana E., Engen, John R.
Publicado em 2012

Applications of Hydrogen/Deuterium Exchange MS from 2012 to 2014

Por Pirrone, Gregory F., Iacob, Roxana E., Engen, John R.
Publicado no Anal Chem (2014)

Mass spectrometric characterization of glycosylation of Hepatitis C virus E2 envelope glycoprotein reveals extended microheterogeneity of N-glycans

Por Iacob, Roxana E., Perdivara, Irina, Przybylski, Michael, Tomer, Kenneth B.
Publicado em 2007

Allosteric Interactions between the Myristate- and ATP-Site of the Abl Kinase

Por Iacob, Roxana E., Zhang, Jianming, Gray, Nathanael S., Engen, John R.
Publicado em 2011

Structure and Dynamic Regulation of Abl Kinases

Por Panjarian, Shoghag, Iacob, Roxana E., Chen, Shugui, Engen, John R., Smithgall, Thomas E.
Publicado em 2013

General structural features that regulate integrin affinity revealed by atypical αVβ8

Por Wang, Jianchuan, Su, Yang, Iacob, Roxana E., Engen, John R., Springer, Timothy A.
Publicado no Nat Commun (2019)

STRUCTURAL ELUCIDATION OF CRITICAL RESIDUES INVOLVED IN BINDING OF HUMAN MONOCLONAL ANTIBODIES TO HEPATITIS C VIRUS E2 ENVELOPE GLYCOPROTEIN

Por Iacob, Roxana E., Keck, Zhenyong, Olson, Oakley, Foung, Steven K.H., Tomer, Kenneth B.
Publicado em 2008

Electron Transfer Control in Soluble Methane Monooxygenase

Por Wang, Weixue, Iacob, Roxana E., Luoh, Rebecca P., Engen, John R., Lippard, Stephen J.
Publicado em 2014

Conformational disturbance in Abl kinase upon mutation and deregulation

Por Iacob, Roxana E., Pene-Dumitrescu, Teodora, Zhang, Jianming, Gray, Nathanael S., Smithgall, Thomas E., Engen, John R.
Publicado em 2009

Enhanced SH3/Linker Interaction Overcomes Abl Kinase Activation by Gatekeeper and Myristic Acid Binding Pocket Mutations and Increases Sensitivity to Small Molecule Inhibitors

Por Panjarian, Shoghag, Iacob, Roxana E., Chen, Shugui, Wales, Thomas E., Engen, John R., Smithgall, Thomas E.
Publicado em 2013

Investigating monoclonal antibody aggregation using a combination of H/DX-MS and other biophysical measurements

Por Iacob, Roxana E., Bou-Assaf, George M., Makowski, Lee, Engen, John R., Berkowitz, Steven A., Houde, Damian
Publicado em 2013

The natural product cucurbitacin E inhibits depolymerization of actin filaments

Por Sörensen, Pia M., Iacob, Roxana E., Fritzsche, Marco, Engen, John R., Brieher, William M., Charras, Guillaume, Eggert, Ulrike S.
Publicado em 2012

Differential Sensitivity of Src-Family Kinases to Activation by SH3 Domain Displacement

Por Moroco, Jamie A., Craigo, Jodi K., Iacob, Roxana E., Wales, Thomas E., Engen, John R., Smithgall, Thomas E.
Publicado em 2014

Hydrogen/Deuterium Exchange Mass Spectrometry for Probing Higher Order Structure of Protein Therapeutics: Methodology and Applications

Por Wei, Hui, Mo, Jingjie, Tao, Li, Russell, Reb J., Tymiak, Adrienne A., Chen, Guodong, Iacob, Roxana E., Engen, John R.
Publicado em 2013

Force Interacts with Macromolecular Structure in Activation of TGF-β

Por Dong, Xianchi, Zhao, Bo, Iacob, Roxana E., Zhu, Jianghai, Koksal, Adem C., Lu, Chafen, Engen, John R., Springer, Timothy A.
Publicado no Nature (2017)

Fusion surface structure, function, and dynamics of gamete fusogen HAP2

Por Feng, Juan, Dong, Xianchi, Pinello, Jennifer, Zhang, Jun, Lu, Chafen, Iacob, Roxana E, Engen, John R, Snell, William J, Springer, Timothy A
Publicado no eLife (2018)

Tolloid cleavage activates latent GDF8 by priming the pro‐complex for dissociation

Por Le, Viet Q, Iacob, Roxana E, Tian, Yuan, McConaughy, William, Jackson, Justin, Su, Yang, Zhao, Bo, Engen, John R, Pirruccello‐Straub, Michelle, Springer, Timothy A
Publicado no EMBO J (2018)

Hydrogen/Deuterium Exchange Mass Spectrometry Applied to IL-23 Interaction Characteristics: Potential Impact for Therapeutics

Por Iacob, Roxana E., Krystek, Stanley R., Huang, Richard Y.-C., Wei, Hui, Tao, Li, Lin, Zheng, Morin, Paul E., Doyle, Michael L., Tymiak, Adrienne A., Engen, John R., Chen, Guodong
Publicado no Expert Rev Proteomics (2015)

The influence of adnectin binding on the extracellular domain of epidermal growth factor receptor

Por Iacob, Roxana E., Chen, Guodong, Ahn, Joomi, Houel, Stephane, Wei, Hui, Mo, Jingjie, Tao, Li, Cohen, Daniel, Xie, Dianlin, Lin, Zheng, Morin, Paul E., Doyle, Michael L., Tymiak, Adrienne A., Engen, John R.
Publicado no J Am Soc Mass Spectrom (2014)

Structure-guided development of a potent and selective noncovalent active site inhibitor of USP7

Por Lamberto, Ilaria, Liu, Xiaoxi, Seo, Hyuk-Soo, Schauer, Nathan J, Iacob, Roxana E, Hu, Wanyi, Das, Deepika, Mikhailova, Tatiana, Weisberg, Ellen L, Engen, John R, Anderson, Kenneth C, Chauhan, Dharminder, Dhe-Paganon, Sirano, Buhrlage, Sara J
Publicado no Cell Chem Biol (2017)