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Force Interacts with Macromolecular Structure in Activation of TGF-β
We show how integrin α(V)β(6) binds a macromolecular ligand, pro-TGF-β1, in an orientation biologically relevant for force-dependent release of TGF-β from latency. The conformation of the prodomain integrin-binding motif differs in presence and absence of integrin binding; differences extend well ou...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5586147/ https://ncbi.nlm.nih.gov/pubmed/28117447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21035 |
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