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High integrin α(V)β(6) affinity reached by hybrid domain deletion slows ligand-binding on-rate
The role of the hybrid domain in integrin affinity regulation is unknown, as is whether the kinetics of ligand binding is modulated by integrin affinity state. Here, we compare cell surface and soluble integrin α(V)β(6) truncation mutants for ligand-binding affinity, kinetics, and thermodynamics. Re...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5816193/ https://ncbi.nlm.nih.gov/pubmed/29378937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718662115 |
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