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Structural determinants of integrin β-subunit specificity for latent TGF-β
Eight integrin α-β heterodimers recognize ligands with an Arg-Gly-Asp (RGD) motif. However, the structural mechanism by which integrins differentiate among extracellular proteins with RGD motifs is not understood. Here, crystal structures, mutations and peptide-affinity measurements show that α(V)β(...
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| 出版年: | Nat Struct Mol Biol |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4717663/ https://ncbi.nlm.nih.gov/pubmed/25383667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2905 |
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