Differential Sensitivity of Src-Family Kinases to Activation by SH3 Domain Displacement

Src-family kinases (SFKs) are non-receptor protein-tyrosine kinases involved in a variety of signaling pathways in virtually every cell type. The SFKs share a common negative regulatory mechanism that involves intramolecular interactions of the SH3 domain with the PPII helix formed by the SH2-kinase...

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Bibliographic Details
Main Authors: Moroco, Jamie A., Craigo, Jodi K., Iacob, Roxana E., Wales, Thomas E., Engen, John R., Smithgall, Thomas E.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140816/
https://ncbi.nlm.nih.gov/pubmed/25144189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105629
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