Enhanced SH3/Linker Interaction Overcomes Abl Kinase Activation by Gatekeeper and Myristic Acid Binding Pocket Mutations and Increases Sensitivity to Small Molecule Inhibitors

Multidomain kinases such as c-Src and c-Abl are regulated by complex allosteric interactions involving their noncatalytic SH3 and SH2 domains. Here we show that enhancing natural allosteric control of kinase activity by SH3/linker engagement has long-range suppressive effects on the kinase activity...

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Hlavní autoři: Panjarian, Shoghag, Iacob, Roxana E., Chen, Shugui, Wales, Thomas E., Engen, John R., Smithgall, Thomas E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585049/
https://ncbi.nlm.nih.gov/pubmed/23303187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.431312
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