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The Abl SH2-kinase linker naturally adopts a conformation competent for SH3 domain binding
The core of the Abelson tyrosine kinase (c-Abl) is structurally similar to Src-family kinases where SH3 and SH2 domains pack against the backside of the kinase domain in the down-regulated conformation. Both kinase families depend upon intramolecular association of SH3 with the linker joining the SH...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2203333/ https://ncbi.nlm.nih.gov/pubmed/17327393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062631007 |
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