The Abl SH2-kinase linker naturally adopts a conformation competent for SH3 domain binding

The core of the Abelson tyrosine kinase (c-Abl) is structurally similar to Src-family kinases where SH3 and SH2 domains pack against the backside of the kinase domain in the down-regulated conformation. Both kinase families depend upon intramolecular association of SH3 with the linker joining the SH...

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Bibliographic Details
Main Authors: Chen, Shugui, Brier, Sébastien, Smithgall, Thomas E., Engen, John R.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2203333/
https://ncbi.nlm.nih.gov/pubmed/17327393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062631007
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