c-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in Solution

[Image: see text] Protein tyrosine kinases of the Abl family have diverse roles in normal cellular regulation and drive several forms of leukemia as oncogenic fusion proteins. In the crystal structure of the inactive c-Abl kinase core, the SH2 and SH3 domains dock onto the back of the kinase domain,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochemistry
Prif Awduron: Badger, John, Grover, Prerna, Shi, Haibin, Panjarian, Shoghag B., Engen, John R., Smithgall, Thomas E., Makowski, Lee
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2016
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910136/
https://ncbi.nlm.nih.gov/pubmed/27166638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00202
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