c-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in Solution

[Image: see text] Protein tyrosine kinases of the Abl family have diverse roles in normal cellular regulation and drive several forms of leukemia as oncogenic fusion proteins. In the crystal structure of the inactive c-Abl kinase core, the SH2 and SH3 domains dock onto the back of the kinase domain,...

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Bibliografiske detaljer
Udgivet i:Biochemistry
Main Authors: Badger, John, Grover, Prerna, Shi, Haibin, Panjarian, Shoghag B., Engen, John R., Smithgall, Thomas E., Makowski, Lee
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2016
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910136/
https://ncbi.nlm.nih.gov/pubmed/27166638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00202
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