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Fluorescence Polarization Screening Assays for Small Molecule Allosteric Modulators of ABL Kinase Function
The ABL protein-tyrosine kinase regulates intracellular signaling pathways controlling diverse cellular processes and contributes to several forms of cancer. The kinase activity of ABL is repressed by intramolecular interactions involving its regulatory Ncap, SH3 and SH2 domains. Small molecules tha...
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| Veröffentlicht in: | PLoS One |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4519180/ https://ncbi.nlm.nih.gov/pubmed/26222440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133590 |
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