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Structure-guided development of a potent and selective noncovalent active site inhibitor of USP7
Deubiquitinating enzymes (DUBs) have garnered significant attention as drug targets in the last 5–10 years. The excitement stems in large part from the powerful ability of DUB inhibitors to promote degradation of oncogenic proteins, especially proteins that are challenging to directly target but whi...
Kaydedildi:
| Yayımlandı: | Cell Chem Biol |
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| Asıl Yazarlar: | , , , , , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2017
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5749250/ https://ncbi.nlm.nih.gov/pubmed/29056421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.09.003 |
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