Structure-guided development of a potent and selective noncovalent active site inhibitor of USP7

Deubiquitinating enzymes (DUBs) have garnered significant attention as drug targets in the last 5–10 years. The excitement stems in large part from the powerful ability of DUB inhibitors to promote degradation of oncogenic proteins, especially proteins that are challenging to directly target but whi...

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Detaylı Bibliyografya
Yayımlandı:Cell Chem Biol
Asıl Yazarlar: Lamberto, Ilaria, Liu, Xiaoxi, Seo, Hyuk-Soo, Schauer, Nathan J, Iacob, Roxana E, Hu, Wanyi, Das, Deepika, Mikhailova, Tatiana, Weisberg, Ellen L, Engen, John R, Anderson, Kenneth C, Chauhan, Dharminder, Dhe-Paganon, Sirano, Buhrlage, Sara J
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749250/
https://ncbi.nlm.nih.gov/pubmed/29056421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.09.003
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