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Structure-guided development of a potent and selective noncovalent active site inhibitor of USP7
Deubiquitinating enzymes (DUBs) have garnered significant attention as drug targets in the last 5–10 years. The excitement stems in large part from the powerful ability of DUB inhibitors to promote degradation of oncogenic proteins, especially proteins that are challenging to directly target but whi...
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| 出版年: | Cell Chem Biol |
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| 主要な著者: | , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2017
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5749250/ https://ncbi.nlm.nih.gov/pubmed/29056421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.09.003 |
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