Structure-guided development of a potent and selective noncovalent active site inhibitor of USP7

Deubiquitinating enzymes (DUBs) have garnered significant attention as drug targets in the last 5–10 years. The excitement stems in large part from the powerful ability of DUB inhibitors to promote degradation of oncogenic proteins, especially proteins that are challenging to directly target but whi...

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書誌詳細
出版年:Cell Chem Biol
主要な著者: Lamberto, Ilaria, Liu, Xiaoxi, Seo, Hyuk-Soo, Schauer, Nathan J, Iacob, Roxana E, Hu, Wanyi, Das, Deepika, Mikhailova, Tatiana, Weisberg, Ellen L, Engen, John R, Anderson, Kenneth C, Chauhan, Dharminder, Dhe-Paganon, Sirano, Buhrlage, Sara J
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749250/
https://ncbi.nlm.nih.gov/pubmed/29056421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.09.003
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