Inhibition of USP10 induces degradation of oncogenic FLT3

Oncogenic FLT3 kinase is an important therapeutic target in acute myeloid leukemia (AML), however clinical responses to small molecule kinase inhibitors are short-lived due to rapid emergence of resistance as a consequence of point mutations or compensatory increases in FLT3 expression. We sought to...

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Veröffentlicht in:Nat Chem Biol
Hauptverfasser: Weisberg, Ellen L., Schauer, Nathan J., Yang, Jing, Lamberto, Ilaria, Doherty, Laura, Bhatt, Shruti, Nonami, Atsushi, Meng, Chengcheng, Letai, Anthony, Wright, Renee, Tiv, Hong, Gokhale, Prafulla C., Ritorto, Maria Stella, De Cesare, Virginia, Trost, Matthias, Christodoulou, Alexandra, Christie, Amanda, Weinstock, David M., Adamia, Sophia, Stone, Richard, Chauhan, Dharminder, Anderson, Kenneth C., Seo, Hyuk-Soo, Dhe-Paganon, Sirano, Sattler, Martin, Gray, Nathanael S., Griffin, James D., Buhrlage, Sara J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314479/
https://ncbi.nlm.nih.gov/pubmed/28967922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2486
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