Inhibition of USP10 induces degradation of oncogenic FLT3

Oncogenic FLT3 kinase is an important therapeutic target in acute myeloid leukemia (AML), however clinical responses to small molecule kinase inhibitors are short-lived due to rapid emergence of resistance as a consequence of point mutations or compensatory increases in FLT3 expression. We sought to...

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Publicat a:Nat Chem Biol
Autors principals: Weisberg, Ellen L., Schauer, Nathan J., Yang, Jing, Lamberto, Ilaria, Doherty, Laura, Bhatt, Shruti, Nonami, Atsushi, Meng, Chengcheng, Letai, Anthony, Wright, Renee, Tiv, Hong, Gokhale, Prafulla C., Ritorto, Maria Stella, De Cesare, Virginia, Trost, Matthias, Christodoulou, Alexandra, Christie, Amanda, Weinstock, David M., Adamia, Sophia, Stone, Richard, Chauhan, Dharminder, Anderson, Kenneth C., Seo, Hyuk-Soo, Dhe-Paganon, Sirano, Sattler, Martin, Gray, Nathanael S., Griffin, James D., Buhrlage, Sara J.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314479/
https://ncbi.nlm.nih.gov/pubmed/28967922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2486
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