Inhibition of USP10 induces degradation of oncogenic FLT3

Oncogenic FLT3 kinase is an important therapeutic target in acute myeloid leukemia (AML), however clinical responses to small molecule kinase inhibitors are short-lived due to rapid emergence of resistance as a consequence of point mutations or compensatory increases in FLT3 expression. We sought to...

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Published in:Nat Chem Biol
Main Authors: Weisberg, Ellen L., Schauer, Nathan J., Yang, Jing, Lamberto, Ilaria, Doherty, Laura, Bhatt, Shruti, Nonami, Atsushi, Meng, Chengcheng, Letai, Anthony, Wright, Renee, Tiv, Hong, Gokhale, Prafulla C., Ritorto, Maria Stella, De Cesare, Virginia, Trost, Matthias, Christodoulou, Alexandra, Christie, Amanda, Weinstock, David M., Adamia, Sophia, Stone, Richard, Chauhan, Dharminder, Anderson, Kenneth C., Seo, Hyuk-Soo, Dhe-Paganon, Sirano, Sattler, Martin, Gray, Nathanael S., Griffin, James D., Buhrlage, Sara J.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314479/
https://ncbi.nlm.nih.gov/pubmed/28967922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2486
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