The combination of FLT3 and SYK kinase inhibitors is toxic to leukaemia cells with CBL mutations

Mutations in the E3 ubiquitin ligase CBL, found in several myeloid neoplasms, lead to decreased ubiquitin ligase activity. In murine systems, these mutations are associated with cytokine‐independent proliferation, thought to result from the activation of hematopoietic growth receptors, including FLT...

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Gepubliceerd in:J Cell Mol Med
Hoofdauteurs: Weisberg, Ellen, Meng, Chengcheng, Case, Abigail E., Tiv, Hong L., Gokhale, Prafulla C., Toure, Anthia A., Buhrlage, Sara, Liu, Xiaoxi, Wang, Jinhua, Gray, Nathanael, Stone, Richard, Adamia, Sophia, Winer, Eric, Sattler, Martin, Griffin, James D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2020
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Original Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7011134/
https://ncbi.nlm.nih.gov/pubmed/31943762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14820
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