Inhibition of the deubiquitinase USP10 induces degradation of SYK

BACKGROUND: There is growing evidence that spleen tyrosine kinase (SYK) is critical for acute myeloid leukaemia (AML) transformation and maintenance of the leukemic clone in AML patients. It has also been found to be over-expressed in AML patients, with activating mutations in foetal liver tyrosine...

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Pubblicato in:Br J Cancer
Autori principali: Yang, Jing, Meng, Chengcheng, Weisberg, Ellen, Case, Abigail, Lamberto, Ilaria, Magin, Robert S., Adamia, Sophia, Wang, Jinhua, Gray, Nathanael, Liu, Suiyang, Stone, Richard, Sattler, Martin, Buhrlage, Sara, Griffin, James D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156412/
https://ncbi.nlm.nih.gov/pubmed/32015510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0731-z
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