Inhibition of the deubiquitinase USP10 induces degradation of SYK

BACKGROUND: There is growing evidence that spleen tyrosine kinase (SYK) is critical for acute myeloid leukaemia (AML) transformation and maintenance of the leukemic clone in AML patients. It has also been found to be over-expressed in AML patients, with activating mutations in foetal liver tyrosine...

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I publikationen:Br J Cancer
Huvudupphovsmän: Yang, Jing, Meng, Chengcheng, Weisberg, Ellen, Case, Abigail, Lamberto, Ilaria, Magin, Robert S., Adamia, Sophia, Wang, Jinhua, Gray, Nathanael, Liu, Suiyang, Stone, Richard, Sattler, Martin, Buhrlage, Sara, Griffin, James D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156412/
https://ncbi.nlm.nih.gov/pubmed/32015510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0731-z
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