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Inhibition of the deubiquitinase USP10 induces degradation of SYK
BACKGROUND: There is growing evidence that spleen tyrosine kinase (SYK) is critical for acute myeloid leukaemia (AML) transformation and maintenance of the leukemic clone in AML patients. It has also been found to be over-expressed in AML patients, with activating mutations in foetal liver tyrosine...
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| Pubblicato in: | Br J Cancer |
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| Autori principali: | , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7156412/ https://ncbi.nlm.nih.gov/pubmed/32015510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0731-z |
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