Inhibition of the deubiquitinase USP10 induces degradation of SYK

BACKGROUND: There is growing evidence that spleen tyrosine kinase (SYK) is critical for acute myeloid leukaemia (AML) transformation and maintenance of the leukemic clone in AML patients. It has also been found to be over-expressed in AML patients, with activating mutations in foetal liver tyrosine...

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Detaylı Bibliyografya
Yayımlandı:Br J Cancer
Asıl Yazarlar: Yang, Jing, Meng, Chengcheng, Weisberg, Ellen, Case, Abigail, Lamberto, Ilaria, Magin, Robert S., Adamia, Sophia, Wang, Jinhua, Gray, Nathanael, Liu, Suiyang, Stone, Richard, Sattler, Martin, Buhrlage, Sara, Griffin, James D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156412/
https://ncbi.nlm.nih.gov/pubmed/32015510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0731-z
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