Inhibition of SDF-1-induced migration of oncogene-driven myeloid leukemia by the L-RNA aptamer (Spiegelmer), NOX-A12, and potentiation of tyrosine kinase inhibition

Por Weisberg, Ellen L., Sattler, Martin, Azab, Abdel Kareem, Eulberg, Dirk, Kruschinski, Anna, Manley, Paul W., Stone, Richard, Griffin, James D.
Publicado no Oncotarget (2017)

Acute myeloid leukemia cells require 6-phosphogluconate dehydrogenase for cell growth and NADPH-dependent metabolic reprogramming

Por Bhanot, Haymanti, Weisberg, Ellen L., Reddy, Mamatha M., Nonami, Atsushi, Neuberg, Donna, Stone, Richard M., Podar, Klaus, Salgia, Ravi, Griffin, James D., Sattler, Martin
Publicado no Oncotarget (2017)

Correction to Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor

Por Kim, Hyung-Gu, Tan, Li, Weisberg, Ellen L., Liu, Feiyang, Canning, Peter, Choi, Hwan-Geun, Ezell, Scott, Zhao, Zheng, Wu, Hong, Wang, Jinhua, Mandinova, Anna, Bullock, Alex N., Liu, Qingsong, Lee, Sam W., Gray, Nathanael S.
Publicado em 2014

Structure-guided development of a potent and selective noncovalent active site inhibitor of USP7

Por Lamberto, Ilaria, Liu, Xiaoxi, Seo, Hyuk-Soo, Schauer, Nathan J, Iacob, Roxana E, Hu, Wanyi, Das, Deepika, Mikhailova, Tatiana, Weisberg, Ellen L, Engen, John R, Anderson, Kenneth C, Chauhan, Dharminder, Dhe-Paganon, Sirano, Buhrlage, Sara J
Publicado no Cell Chem Biol (2017)

Pathological glycogenesis through glycogen synthase 1 and suppression of excessive AMP kinase activity in myeloid leukemia cells

Por Bhanot, Haymanti, Reddy, Mamatha M., Nonami, Atsushi, Weisberg, Ellen L., Bonal, Dennis, Kirschmeier, Paul T., Salgia, Sabrina, Podar, Klaus, Galinsky, Ilene, Chowdary, Tirumala K., Neuberg, Donna, Tonon, Giovanni, Stone, Richard M., Asara, John, Griffin, James D., Sattler, Martin
Publicado no Leukemia (2015)

Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor

Por Kim, Hyung-Gu, Tan, Li, Weisberg, Ellen L., Liu, Feiyang, Canning, Peter, Choi, Hwan Geun, Ezell, Scott A., Wu, Hong, Zhao, Zheng, Wang, Jinhua, Mandinova, Anna, Griffin, James D., Bullock, Alex N., Liu, Qingsong, Lee, Sam W., Gray, Nathanael S.
Publicado em 2013

Ibrutinib Selectively Targets FLT3-ITD in Mutant FLT3-Positive AML

Por Wu, Hong, Hu, Chen, Wang, Aoli, Weisberg, Ellen L., Wang, Wenchao, Chen, Cheng, Zhao, Zheng, Yu, Kailin, Liu, Juan, Wu, Jiaxin, Nonami, Atsushi, Wang, Li, Wang, Beilei, Stone, Richard M., Liu, Suiyang, Griffin, James D., Liu, Jing, Liu, Qingsong
Publicado no Leukemia (2015)

Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors

Por Tan, Li, Gurbani, Deepak, Weisberg, Ellen L., Jones, Douglas S., Rao, Suman, Singer, William D., Bernard, Faviola M., Mowafy, Samar, Jenney, Annie, Du, Guangyan, Nonami, Atsushi, Griffin, James D., Lauffenburger, Douglas A., Westover, Kenneth D., Sorger, Peter K., Gray, Nathanael S.
Publicado no Bioorg Med Chem (2016)

Characterization of midostaurin as a dual inhibitor of FLT3 and SYK and potentiation of FLT3 inhibition against FLT3-ITD-driven leukemia harboring activated SYK kinase

Por Weisberg, Ellen L., Puissant, Alexandre, Stone, Richard, Sattler, Martin, Buhrlage, Sara J., Yang, Jing, Manley, Paul W., Meng, Chengcheng, Buonopane, Michael, Daley, John F., Lazo, Suzan, Wright, Renee, Weinstock, David M., Christie, Amanda L., Stegmaier, Kimberly, Griffin, James D.
Publicado no Oncotarget (2017)

Structure-guided development of covalent TAK1 inhibitors

Por Tan, Li, Gurbani, Deepak, Weisberg, Ellen L., Hunter, John C., Li, Lianbo, Jones, Douglas S., Ficarro, Scott B., Mowafy, Samar, Tam, Chun-Pong, Rao, Suman, Du, Guangyan, Griffin, James D., Sorger, Peter K., Marto, Jarrod A., Westover, Kenneth D., Gray, Nathanael S.
Publicado no Bioorg Med Chem (2016)

Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation

Por Wang, Aoli, Yan, Xiao-E, Wu, Hong, Wang, Wenchao, Hu, Chen, Chen, Cheng, Zhao, Zheng, Zhao, Peng, Li, Xixiang, Wang, Li, Wang, Beilei, Ye, Zi, Wang, Jinhua, Wang, Chu, Zhang, Wei, Gray, Nathanael S., Weisberg, Ellen L., Chen, Liang, Liu, Jing, Yun, Cai-Hong, Liu, Qingsong
Publicado no Oncotarget (2016)

Dual inhibition of AKT/FLT3-ITD by A674563 overcomes FLT3 ligand-induced drug resistance in FLT3-ITD positive AML

Por Wang, Aoli, Wu, Hong, Chen, Cheng, Hu, Chen, Qi, Ziping, Wang, Wenchao, Yu, Kailin, Liu, Xiaochuan, Zou, Fengming, Zhao, Zheng, Wu, Jiaxin, Liu, Juan, Liu, Feiyang, Wang, Li, Stone, Richard M., Galinksy, Ilene A., Griffin, James D., Zhang, Shanchun, Weisberg, Ellen L., Liu, Jing, Liu, Qingsong
Publicado no Oncotarget (2016)

A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader

Por Huang, Hai-Tsang, Dobrovolsky, Dennis, Paulk, Joshiawa, Yang, Guang, Weisberg, Ellen L., Doctor, Zainab M., Buckley, Dennis L., Cho, Joong-Heui, Ko, Eunhwa, Jang, Jaebong, Shi, Kun, Choi, Hwan Geun, Griffin, James D., Li, Ying, Treon, Steven P., Fischer, Eric S., Bradner, James E., Tan, Li, Gray, Nathanael S.
Publicado no Cell Chem Biol (2017)

Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells

Por Wu, Hong, Wang, Aoli, Zhang, Wei, Wang, Beilei, Chen, Cheng, Wang, Wenchao, Hu, Chen, Ye, Zi, Zhao, Zheng, Wang, Li, Li, Xixiang, Yu, Kailin, Liu, Juan, Wu, Jiaxin, Yan, Xiao-E, Zhao, Peng, Wang, Jinhua, Wang, Chu, Weisberg, Ellen L., Gray, Nathanael S., Yun, Cai-Hong, Liu, Jing, Chen, Liang, Liu, Qingsong
Publicado no Oncotarget (2015)

Discovery of a Potent, Covalent BTK Inhibitor for B-Cell Lymphoma

Por Wu, Hong, Wang, Wenchao, Liu, Feiyang, Weisberg, Ellen L., Tian, Bei, Chen, Yongfei, Li, Binhua, Wang, Aoli, Wang, Beilei, Zhao, Zheng, McMillin, Douglas W., Hu, Chen, Li, Hong, Wang, Jinhua, Liang, Yanke, Buhrlage, Sara J., Liang, Junting, Liu, Jing, Yang, Guang, Brown, Jennifer R., Treon, Steven P., Mitsiades, Constantine S., Griffin, James D., Liu, Qingsong, Gray, Nathanael S.
Publicado em 2014

Discovery of a Highly Potent FLT3 Kinase Inhibitor for FLT3-ITD-Positive AML

Por Wu, Hong, Wang, Aoli, Qi, Ziping, Li, Xixiang, Chen, Cheng, Yu, Kailin, Zou, Fengming, Hu, Chen, Wang, Wenchao, Zhao, Zheng, Wu, Jiaxin, Liu, Juan, liu, Xiaochuan, Wang, Li, Wang, Wei, Zhang, Shanchun, Stone, Richard M., Galinsky, Ilene A., Griffin, James D., Weinstock, David, Christodoulou, Alexandra, Wang, Huiping, Shen, Yuanyuan, Zhai, Zhimin, Weisberg, Ellen L., Liu, Jing, Liu, Qingsong
Publicado no Leukemia (2016)

Characterization of selective and potent PI3Kδ inhibitor (PI3KD-IN-015) for B-Cell malignances

Por Liu, Xiaochuan, Wang, Aoli, Liang, Xiaofei, Chen, Cheng, Liu, Juanjuan, Zhao, Zheng, Wu, Hong, Deng, Yuanxin, Wang, Li, Wang, Beilei, Wu, Jiaxin, Liu, Feiyang, Fernandes, Stacey M., Adamia, Sophia, Stone, Richard M., Galinsky, Ilene A., Brown, Jennifer R., Griffin, James D., Zhang, Shanchun, Loh, Teckpeng, Zhang, Xin, Wang, Wenchao, Weisberg, Ellen L., Liu, Jing, Liu, Qingsong
Publicado no Oncotarget (2016)

Simultaneous inhibition of Vps34 kinase would enhance PI3Kδ inhibitor cytotoxicity in the B-cell malignancies

Por Liu, Xiaochuan, Wang, Aoli, Liang, Xiaofei, Liu, Juanjuan, Zou, Fengming, Chen, Cheng, Zhao, Zheng, Deng, Yuanxin, Wu, Hong, Qi, Ziping, Wang, Beilei, Wang, Li, Liu, Feiyang, Xu, Yunhe, Wang, Wenchao, Fernandes, Stacey M., Stone, Richard M., Galinsky, Ilene A., Brown, Jennifer R., Loh, Teckpeng, Griffin, James. D., Zhang, Shanchun, Weisberg, Ellen L., Zhang, Xin, Liu, Jing, Liu, Qingsong
Publicado no Oncotarget (2016)

Inhibition of USP10 induces degradation of oncogenic FLT3

Por Weisberg, Ellen L., Schauer, Nathan J., Yang, Jing, Lamberto, Ilaria, Doherty, Laura, Bhatt, Shruti, Nonami, Atsushi, Meng, Chengcheng, Letai, Anthony, Wright, Renee, Tiv, Hong, Gokhale, Prafulla C., Ritorto, Maria Stella, De Cesare, Virginia, Trost, Matthias, Christodoulou, Alexandra, Christie, Amanda, Weinstock, David M., Adamia, Sophia, Stone, Richard, Chauhan, Dharminder, Anderson, Kenneth C., Seo, Hyuk-Soo, Dhe-Paganon, Sirano, Sattler, Martin, Gray, Nathanael S., Griffin, James D., Buhrlage, Sara J.
Publicado no Nat Chem Biol (2017)

Discovery of a BTK/MNK Dual Inhibitor for Lymphoma and Leukemia

Por Wu, Hong, Hu, Chen, Wang, Aoli, Weisberg, Ellen L., Chen, Yongfei, Yun, Cai-Hong, Wang, Wenchao, Liu, Yan, Liu, Xiaochuan, Tian, Bei, Wang, Jinhua, Zhao, Zheng, Liang, Yanke, Li, Binhua, Wang, Li, Wang, Beilei, Chen, Cheng, Buhrlage, Sara J., Nonami, Atsushi, Li, Yuyang, Fernandes, Stacey M., Adamia, Sophia, Stone, Richard M., Galinsky, Ilene A., Wang, Xianhuo, Yang, Guang, Griffin, James D., Brown, Jennifer R., Eck, Michael J., Liu, Jing, Gray, Nathanael S., Liu, Qingsong
Publicado no Leukemia (2015)