Characterization of TAE684 as a potent LRRK2 kinase inhibitor

nork Zhang, Jinwei, Deng, Xianming, Choi, Hwan Geun, Alessi, Dario R., Gray, Nathanael S.
Argitaratua 2012

Development of ‘DFG-out’ inhibitors of gatekeeper mutant kinases

nork Choi, Hwan Geun, Zhang, Jianming, Weisberg, Ellen, Griffin, James D., Sim, Taebo, Gray, Nathanael S.
Argitaratua 2012

Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor

nork Hatcher, John M., Zhang, Jinwei, Choi, Hwan Geun, Ito, Genta, Alessi, Dario R., Gray, Nathanael S.
Argitaratua izan da ACS Med Chem Lett (2015)

Structural basis of mutant-selectivity and drug-resistance related to CO-1686

nork Yan, Xiao-E, Zhu, Su-Jie, Liang, Ling, Zhao, Peng, Choi, Hwan Geun, Yun, Cai-Hong
Argitaratua izan da Oncotarget (2017)

Essential Role for IKKβ in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells

nork Pauls, Eduardo, Shpiro, Natalia, Peggie, Mark, Young, Erick R., Sorcek, Ronald J., Tan, Li, Choi, Hwan Geun, Cohen, Philip
Argitaratua 2012

Discovery of inhibitors that overcome the G1202R ALK Resistance Mutation

nork Hatcher, John M., Bahcall, Magda, Choi, Hwan Geun, Gao, Yang, Sim, Taebo, George, Rani, Jänne, Pasi A., Gray, Nathanael S.
Argitaratua izan da J Med Chem (2015)

Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor–associated kinase 4 (IRAK4)

nork Wang, Li, Ferrao, Ryan, Li, Qiubai, Hatcher, John M., Choi, Hwan Geun, Buhrlage, Sara J., Gray, Nathanael S., Wu, Hao
Argitaratua izan da J Biol Chem (2019)

Brain Penetrant LRRK2 Inhibitor

nork Choi, Hwan Geun, Zhang, Jinwei, Deng, Xianming, Hatcher, John M., Patricelli, Matthew P., Zhao, Zheng, Alessi, Dario R., Gray, Nathanael S.
Argitaratua 2012

EGFR mutations and resistance to Irreversible pyrimidine based EGFR inhibitors

nork Ercan, Dalia, Choi, Hwan Geun, Yun, Cai-Hong, Capelletti, Marzia, Xie, Ting, Eck, Michael J., Gray, Nathanael S., Jänne, Pasi A.
Argitaratua izan da Clin Cancer Res (2015)

A Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region

nork Moroco, Jamie A., Baumgartner, Matthew P., Rust, Heather L., Choi, Hwan Geun, Hur, Wooyoung, Gray, Nathanael S., Camacho, Carlos J., Smithgall, Thomas E.
Argitaratua izan da Chem Biol Drug Des (2014)

Beneficial effects of combining a Type II ATP competitive inhibitor with an allosteric competitive inhibitor of Bcr-Abl for the treatment of imatinib-sensitive and imatinib resista...

nork Weisberg, Ellen, Deng, Xianming, Choi, Hwan Geun, Barrett, Rosemary, Adamia, Sophia, Ray, Arghya, Moreno, Daisy, Kung, Andrew L., Gray, Nathanael, Griffin, James D.
Argitaratua 2010

Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stability

nork Liu, Qingsong, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Hur, Wooyoung, Choi, Hwan Geun, Waller, David L., Sim, Taebo, Sabatini, David M., Gray, Nathanael S.
Argitaratua 2011

GSK2578215A; A potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor

nork Reith, Alastair D., Bamborough, Paul, Jandu, Karamjit, Andreotti, Daniele, Mensah, Lucy, Dossang, Pamela, Choi, Hwan Geun, Deng, Xianming, Zhang, Jinwei, Alessi, Dario R., Gray, Nathanael S.
Argitaratua 2012

EphA2 is a Mediator of Vemurafenib Resistance and a Novel Therapeutic Target in Melanoma

nork Miao, Benchun, Ji, Zhenyu, Tan, Li, Taylor, Michael, Zhang, Jianming, Choi, Hwan Geun, Frederick, Dennie T., Kumar, Raj, Wargo, Jennifer A., Flaherty, Keith T., Gray, Nathanael S., Tsao, Hensin
Argitaratua izan da Cancer Discov (2014)

Discovery of a Potent Dual ALK and EGFR T790M Inhibitor

nork Jang, Jaebong, Son, Jung Beom, To, Ciric, Bahcall, Magda, Kim, So Young, Kang, Seock Yong, Mushajiang, Mierzhati, Lee, Younho, Jänne, Pasi A., Choi, Hwan Geun, Gray, Nathanael S.
Argitaratua izan da Eur J Med Chem (2017)

Covalent Guanosine Mimetic Inhibitors of G12C KRAS

nork Xiong, Yuan, Lu, Jia, Hunter, John, Li, Lianbo, Scott, David, Choi, Hwan Geun, Lim, Sang Min, Manandhar, Anuj, Gondi, Sudershan, Sim, Taebo, Westover, Kenneth D., Gray, Nathanael S.
Argitaratua izan da ACS Med Chem Lett (2016)

Brain injury induces HIF-1α-dependent transcriptional activation of LRRK2 that exacerbates brain damage

nork Bae, Yun-Hee, Joo, Hyejin, Bae, Jinhyun, Hyeon, Seung Jae, Her, Song, Ko, Eunhwa, Choi, Hwan Geun, Ryu, Hoon, Hur, Eun-Mi, Bu, Youngmin, Lee, Byoung Dae
Argitaratua izan da Cell Death Dis (2018)

Small Molecule Inhibitors of the c-Fes Protein-tyrosine Kinase

nork Hellwig, Sabine, Miduturu, Chandra V., Kanda, Shigeru, Zhang, Jianming, Filippakopoulos, Panagis, Salah, Eidarus, Deng, Xianming, Choi, Hwan Geun, Zhou, Wenjun, Hur, Wooyoung, Knapp, Stefan, Gray, Nathanael S., Smithgall, Thomas E.
Argitaratua 2012

In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C

nork Hunter, John C., Gurbani, Deepak, Ficarro, Scott B., Carrasco, Martin A., Lim, Sang Min, Choi, Hwan Geun, Xie, Ting, Marto, Jarrod A., Chen, Zhe, Gray, Nathanael S., Westover, Kenneth D.
Argitaratua 2014

Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase

nork Moccia, Marialuisa, Liu, Qingsong, Guida, Teresa, Federico, Giorgia, Brescia, Annalisa, Zhao, Zheng, Choi, Hwan Geun, Deng, Xianming, Tan, Li, Wang, Jinhua, Billaud, Marc, Gray, Nathanael S., Carlomagno, Francesca, Santoro, Massimo
Argitaratua izan da PLoS One (2015)