Essential Role for IKKβ in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells

Plasmacytoid dendritic cells (pDCs) are characterized by their ability to produce high levels of type 1 interferons in response to ligands that activate TLR7 and TLR9, but the signaling pathways required for IFN production are incompletely understood. Here we exploit the human pDC cell line Gen2.2 a...

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Detalhes bibliográficos
Main Authors: Pauls, Eduardo, Shpiro, Natalia, Peggie, Mark, Young, Erick R., Sorcek, Ronald J., Tan, Li, Choi, Hwan Geun, Cohen, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365954/
https://ncbi.nlm.nih.gov/pubmed/22511786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.345405
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