GSK2578215A; A potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor

Leucine-rich repeat kinase 2 (LRRK2) is a promising therapeutic target for some forms of Parkinson’s disease. Here we report the discovery and characterization of 2-arylmethyloxy-5-subtitutent-N-arylbenzamides with potent LRRK2 activities exemplified by GSK2578215A which exhibits biochemical IC(50)s...

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Hlavní autoři: Reith, Alastair D., Bamborough, Paul, Jandu, Karamjit, Andreotti, Daniele, Mensah, Lucy, Dossang, Pamela, Choi, Hwan Geun, Deng, Xianming, Zhang, Jinwei, Alessi, Dario R., Gray, Nathanael S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4208292/
https://ncbi.nlm.nih.gov/pubmed/22863203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.06.104
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