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Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson’s disease
The LRRK2 (leucine-rich repeat protein kinase-2) is mutated in a significant number of Parkinson’s disease patients, but little is known about its regulation and function. A common mutation changing Gly(2019) to serine enhances catalytic activity, suggesting that small-molecule inhibitors might have...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3759966/ https://ncbi.nlm.nih.gov/pubmed/19740074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20091035 |
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