14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

LRRK2 (leucine-rich repeat protein kinase 2) is mutated in a significant number of Parkinson's disease patients, but still little is understood about how it is regulated or functions. In the present study we have demonstrated that 14-3-3 protein isoforms interact with LRRK2. Consistent with thi...

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Autores principales: Nichols, R. Jeremy, Dzamko, Nicolas, Morrice, Nicholas A., Campbell, David G., Deak, Maria, Ordureau, Alban, Macartney, Thomas, Tong, Youren, Shen, Jie, Prescott, Alan R., Alessi, Dario R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Portland Press Ltd. 2010
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932554/
https://ncbi.nlm.nih.gov/pubmed/20642453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20100483
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