LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

Mutations in the LRRK2 (leucine-rich repeat kinase-2) gene cause late-onset PD (Parkinson's disease). LRRK2 contains leucine-rich repeats, a GTPase domain, a COR [C-terminal of Roc (Ras of complex)] domain, a kinase and a WD40 (Trp-Asp 40) motif. Little is known about how LRRK2 is regulated, wh...

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Hlavní autoři: Jaleel, Mahaboobi, Nichols, R. Jeremy, Deak, Maria, Campbell, David G., Gillardon, Frank, Knebel, Axel, Alessi, Dario R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2007
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904520/
https://ncbi.nlm.nih.gov/pubmed/17447891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070209
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