The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been associated with Parkinson's disease, and its inhibition opens potential new therapeutic options. Among the drug inhibitors of both wild-type and mutant LRRK2 forms is the 2-arylmethyloxy-5-subtitutent-N-arylbenzamide GSK257815...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Saez-Atienzar, S, Bonet-Ponce, L, Blesa, J R, Romero, F J, Murphy, M P, Jordan, J, Galindo, M F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454299/
https://ncbi.nlm.nih.gov/pubmed/25118928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.320
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