LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation

Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease (PD). LRRK2 contains a functional kinase domain and G2019S, the most prevalent LRRK2 pathogenic mutation, increases its kinase activity. LRRK2 regulates mitochondria morphology and autophagy...

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Detalhes bibliográficos
Publicado no:Exp Neurobiol
Main Authors: Ho, Dong Hwan, Je, A Reum, Lee, Haejin, Son, Ilhong, Kweon, Hee-Seok, Kim, Hyung-Gun, Seol, Wongi
Formato: Artigo
Idioma:Inglês
Publicado em: The Korean Society for Brain and Neural Science 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050415/
https://ncbi.nlm.nih.gov/pubmed/30022868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5607/en.2018.27.3.171
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