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Upregulation of the p53-p21 pathway by G2019S LRRK2 contributes to the cellular senescence and accumulation of α-synuclein

Parkinson’s disease (PD) is characterized by the degeneration of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (LB) in neurons. α-Synuclein (αSyn) is a major component of LB and promote the PD pathogenesis via its accumulation by the impaired proteasomal or autophagic...

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Publicat a:Cell Cycle
Autors principals: Ho, Dong Hwan, Seol, Wongi, Son, Ilhong
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422450/
https://ncbi.nlm.nih.gov/pubmed/30712480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2019.1577666
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