LRRK2 Kinase Inhibitor Rejuvenates Oxidative Stress-Induced Cellular Senescence in Neuronal Cells

BACKGROUND: Leucine-rich repeat kinase 2 (LRRK2) plays a critical role in the pathogenesis of Parkinson's disease (PD). Aging is the most critical risk factor for the progression of PD. The correlation between aging and cellular senescence has been established. Cellular senescence is correlated...

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Udgivet i:Oxid Med Cell Longev
Main Authors: Ho, Dong Hwan, Nam, Daleum, Seo, Mi Kyoung, Park, Sung Woo, Seol, Wongi, Son, Ilhong
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8282384/
https://ncbi.nlm.nih.gov/pubmed/34306319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/9969842
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