Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression

BACKGROUND: Leucine-rich repeat kinase 2 (LRRK2) is a gene in which a mutation causes Parkinson’s disease (PD), and p53 is a prototype tumor suppressor. In addition, activation of p53 in patient with PD has been reported by several studies. Because phosphorylation of p53 is critical for regulating i...

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Veröffentlicht in:Mol Brain
Hauptverfasser: Ho, Dong Hwan, Kim, Hyejung, Kim, Jisun, Sim, Hyuna, Ahn, Hyunjun, Kim, Janghwan, Seo, Hyemyung, Chung, Kwang Chul, Park, Bum-Joon, Son, Ilhong, Seol, Wongi
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575451/
https://ncbi.nlm.nih.gov/pubmed/26384650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-015-0145-7
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