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G2385R and I2020T Mutations Increase LRRK2 GTPase Activity
The LRRK2 mutation is a major causal mutation in familial Parkinson's disease. Although LRRK2 contains functional GTPase and kinase domains and their activities are altered by pathogenic mutations, most studies focused on LRRK2 kinase activity because the most prevalent mutant, G2019S, enhances...
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| Publicado no: | Biomed Res Int |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Hindawi Publishing Corporation
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4897664/ https://ncbi.nlm.nih.gov/pubmed/27314038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/7917128 |
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