Increase in anti-apoptotic molecules, nucleolin, and heat shock protein 70, against upregulated LRRK2 kinase activity

Leucine-rich repeat kinase 2 (LRRK2) is involved in Parkinson’s disease (PD) pathology. A previous study showed that rotenone treatment induced apoptosis, mitochondrial damage, and nucleolar disruption via up-regulated LRRK2 kinase activity, and these effects were rescued by an LRRK2 kinase inhibito...

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Detalhes bibliográficos
Publicado no:Anim Cells Syst (Seoul)
Main Authors: Jang, Jihoon, Oh, Hakjin, Nam, Daleum, Seol, Wongi, Seo, Mi Kyoung, Park, Sung Woo, Kim, Hyung Gun, Seo, Hyemyung, Son, Ilhong, Ho, Dong Hwan
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6171436/
https://ncbi.nlm.nih.gov/pubmed/30460108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19768354.2018.1518262
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