Small Molecule Inhibitors of the c-Fes Protein-tyrosine Kinase

The c-Fes protein-tyrosine kinase modulates cellular signaling pathways governing differentiation, the innate immune response, and vasculogenesis. Here we report the identification of Type I and II kinase inhibitors with potent activity against c-Fes both in vitro and in cell-based assays. One of th...

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Detalhes bibliográficos
Main Authors: Hellwig, Sabine, Miduturu, Chandra V., Kanda, Shigeru, Zhang, Jianming, Filippakopoulos, Panagis, Salah, Eidarus, Deng, Xianming, Choi, Hwan Geun, Zhou, Wenjun, Hur, Wooyoung, Knapp, Stefan, Gray, Nathanael S., Smithgall, Thomas E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334838/
https://ncbi.nlm.nih.gov/pubmed/22520759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.01.020
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