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Dual inhibition of Fes and Flt3 tyrosine kinases potently inhibits Flt3-ITD(+) AML cell growth

Acute myelogenous leukemia (AML) is often associated with activating mutations in the receptor tyrosine kinase, Flt3, including internal tandem duplications (ITDs) within the regulatory juxtamembrane region. Previous studies have linked Flt3-ITD to the activation of the Fes protein tyrosine kinase i...

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Publié dans:PLoS One
Auteurs principaux: Weir, Mark C., Hellwig, Sabine, Tan, Li, Liu, Yao, Gray, Nathanael S., Smithgall, Thomas E.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519068/
https://ncbi.nlm.nih.gov/pubmed/28727840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181178
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