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Selective inhibition of the myeloid Src-family kinase Fgr potently suppresses AML cell growth in vitro and in vivo

Acute myelogenous leukemia (AML) is the most common hematologic malignancy in adults, and is often associated with constitutive tyrosine kinase signaling. These pathways involve the non-receptor tyrosine kinases Fes, Syk and the three Src-family kinases expressed in myeloid cells (Fgr, Hck, and Lyn)...

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Pubblicato in:ACS Chem Biol
Autori principali: Weir, Mark C., Shu, Sherry T., Patel, Ravi K., Hellwig, Sabine, Chen, Li, Tan, Li, Gray, Nathanael S., Smithgall, Thomas E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130198/
https://ncbi.nlm.nih.gov/pubmed/29763550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00154
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