Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance

Unregulated protein-tyrosine kinase signaling is a common feature of AML, often involving mutations in Flt3 and overexpression of myeloid Src-family kinases (Hck, Fgr, Lyn). Here we show that high-level expression of these Src kinases predicts poor survival in a large cohort of AML patients. To test...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Patel, Ravi K., Weir, Mark C., Shen, Kexin, Snyder, Daniel, Cooper, Vaughn S., Smithgall, Thomas E.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6886798/
https://ncbi.nlm.nih.gov/pubmed/31790499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0225887
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker