Terminal myeloid differentiation in vivo is induced by FLT3 inhibition in FLT3/ITD AML

A hallmark of cancer is the disruption of differentiation within tumor cells. Internal tandem duplication mutations of the FLT3 kinase (FLT3/ITD) occur commonly in acute myeloid leukemia (AML) and are associated with poor survival, leading to efforts to develop FLT3 kinase inhibitors. However, FLT3...

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Autori principali: Sexauer, Amy, Perl, Alexander, Yang, Xiaochuan, Borowitz, Michael, Gocke, Christopher, Rajkhowa, Trivikram, Thiede, Christian, Frattini, Mark, Nybakken, Grant E., Pratz, Keith, Karp, Judith, Smith, B. Douglas, Levis, Mark
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2012
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501718/
https://ncbi.nlm.nih.gov/pubmed/23012328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-402545
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